QR-Code

Dapagliflozin alleviates myocardial ischemia/reperfusion injury by reducing ferroptosis via MAPK signaling inhibition

Reperfusion is essential for ischemic myocardium but paradoxically leads to myocardial damage that worsens cardiac functions. Ferroptosis often occurs in cardiomyocytes during ischemia/reperfusion (I/R). The SGLT2 inhibitor dapagliflozin (DAPA) exerts cardioprotective effects independent of hypoglyc...

Ausführliche Beschreibung

Gespeichert in:
Hauptverfasser: Weixiang Chen, Yue Zhang, Zuoxiang Wang, Mingyue Tan, Jia Lin, Xiaodong Qian, Hongxia Li, Tingbo Jiang
Format: Artigo
Sprache:Inglês
Veröffentlicht: Frontiers Media S.A. 2023-02-01
Schriftenreihe:Frontiers in Pharmacology
Schlagworte:
myocardial ischemia/reperfusion
dapagliflozin
ferroptosis
MAPK pathway
treatment
Online-Zugang:https://www.frontiersin.org/articles/10.3389/fphar.2023.1078205/full
Tags: Tag hinzufügen
Keine Tags, Fügen Sie das erste Tag hinzu!

Ähnliche Einträge