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Dapagliflozin alleviates myocardial ischemia/reperfusion injury by reducing ferroptosis via MAPK signaling inhibition

Reperfusion is essential for ischemic myocardium but paradoxically leads to myocardial damage that worsens cardiac functions. Ferroptosis often occurs in cardiomyocytes during ischemia/reperfusion (I/R). The SGLT2 inhibitor dapagliflozin (DAPA) exerts cardioprotective effects independent of hypoglyc...

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Principais autores: Weixiang Chen, Yue Zhang, Zuoxiang Wang, Mingyue Tan, Jia Lin, Xiaodong Qian, Hongxia Li, Tingbo Jiang
Format: Artigo
Sprog:Inglês
Udgivet: Frontiers Media S.A. 2023-02-01
Serier:Frontiers in Pharmacology
Fag:
myocardial ischemia/reperfusion
dapagliflozin
ferroptosis
MAPK pathway
treatment
Online adgang:https://www.frontiersin.org/articles/10.3389/fphar.2023.1078205/full
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