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Associations of cholinergic system integrity with cognitive decline in GBA1 and LRRK2 mutation carriers

Abstract In Parkinson’s disease (PD), GBA1- and LRRK2-mutations are associated with different clinical phenotypes which might be related to differential involvement of the cholinergic system. We investigated cholinergic integrity in 149 asymptomatic GBA1 and 169 asymptomatic LRRK2 mutation carriers,...

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Principais autores: Julia Schumacher, Nicola Ray, Stefan Teipel, Alexander Storch
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Portfolio 2024-06-01
coleção:npj Parkinson's Disease
Acesso em linha:https://doi.org/10.1038/s41531-024-00743-w
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