Immunogenicity of Immunotoxins Containing Pseudomonas Exotoxin A: Causes, Consequences, and Mitigation

Immunotoxins are cytolytic fusion proteins developed for cancer therapy, composed of an antibody fragment that binds to a cancer cell and a protein toxin fragment that kills the cell. Pseudomonas exotoxin A (PE) is a potent toxin that is used for the killing moiety in many immunotoxins. Moxetumomab...

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Autors principals:	Ronit Mazor, Ira Pastan
Format:	Artigo
Idioma:	Inglês
Publicat:	Frontiers Media S.A. 2020-06-01
Col·lecció:	Frontiers in Immunology
Matèries:	recombinant immunotoxins neutralizing antibodies anti-drug antibodies (ADA) B cell epitopes T cell epitopes moxetumomab pasudotox
Accés en línia:	https://www.frontiersin.org/article/10.3389/fimmu.2020.01261/full
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