Protection of the Furin Cleavage Site in Low-Toxicity Immunotoxins Based on Pseudomonas Exotoxin A
Recombinant immunotoxins (RITs) are fusions of an Fv-based targeting moiety and a toxin. Pseudomonas exotoxin A (PE) has been used to make several immunotoxins that have been evaluated in clinical trials. Immunogenicity of the bacterial toxin and off-target toxicity have limited the efficacy of thes...
Zapisane w:
| Główni autorzy: | , , , , , , |
|---|---|
| Format: | Artigo |
| Język: | Inglês |
| Wydane: |
MDPI AG
2016-07-01
|
| Seria: | Toxins |
| Hasła przedmiotowe: | |
| Dostęp online: | http://www.mdpi.com/2072-6651/8/8/217 |
| Etykiety: |
Nie ma etykietki, Dołącz pierwszą etykiete!
|