Immunogenicity of Immunotoxins Containing Pseudomonas Exotoxin A: Causes, Consequences, and Mitigation

Immunotoxins are cytolytic fusion proteins developed for cancer therapy, composed of an antibody fragment that binds to a cancer cell and a protein toxin fragment that kills the cell. Pseudomonas exotoxin A (PE) is a potent toxin that is used for the killing moiety in many immunotoxins. Moxetumomab...

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Principais autores:	Ronit Mazor, Ira Pastan
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Frontiers Media S.A. 2020-06-01
coleção:	Frontiers in Immunology
Assuntos:	recombinant immunotoxins neutralizing antibodies anti-drug antibodies (ADA) B cell epitopes T cell epitopes moxetumomab pasudotox
Acesso em linha:	https://www.frontiersin.org/article/10.3389/fimmu.2020.01261/full
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