Towards Imaging Tau Hyperphosphorylation: Is DYRK1A a Potential Target for Imaging Hyperphosphorylation of Tau? Molecular Modeling Assessment and Synthesis of [¹²⁵I]Radioiodinated DYRK1A Inhibitor

Dual specificity tyrosine-phosphorylation regulated kinase 1A (DYRK1A), a phosphorylation kinase, is localized within the central nervous system and is linked to hyperphosphorylation of Tau. Imaging of DYRK1A may provide an earlier biomarker for Tauopathies, including Alzheimer’s disease (AD). We ha...

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Hlavní autoři:	Cayz G. Paclibar, Deanna M. Schafer, Agnes P. Biju, Fariha Karim, Stephanie A. Sison, Christopher Liang, Shamiha T. Ahmed, Jogeshwar Mukherjee
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	MDPI AG 2025-02-01
Edice:	Molecules
Témata:	[<sup>125</sup>I]IPPI [<sup>125</sup>I]KuFal184 DYRK1A post-mortem human Tau Alzheimer’s disease down syndrome
On-line přístup:	https://www.mdpi.com/1420-3049/30/5/990
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