Targeting feed-forward signaling of TGFβ/NOX4/DHFR/eNOS uncoupling/TGFβ axis with anti-TGFβ and folic acid attenuates formation of aortic aneurysms: Novel mechanisms and therapeutics

In the present study we aimed to identify novel mechanisms and therapeutics for thoracic aortic aneurysm (TAA) in Fbn1C1039G/+ Marfan Syndrome (MFS) mice. The expression of mature/active TGFβ and its downstream effector NOX4 were upregulated while tetrahydrobiopterin (H4B) salvage enzyme dihydrofola...

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Principais autores:	Kai Huang, Yongchen Wang, Kin Lung Siu, Yixuan Zhang, Hua Cai
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Elsevier 2021-01-01
coleção:	Redox Biology
Assuntos:	NADPH oxidase (NOX) NOX isoform 4 (NOX4) Reactive oxygen species (ROS) eNOS uncoupling/recoupling Thoracic aortic aneurysm (TAA) Marfan syndrome (MFS)
Acesso em linha:	http://www.sciencedirect.com/science/article/pii/S2213231720309629
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