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Endothelial dysfunction due to eNOS uncoupling: molecular mechanisms as potential therapeutic targets

Abstract Nitric oxide (NO) is one of the most important molecules released by endothelial cells, and its antiatherogenic properties support cardiovascular homeostasis. Diminished NO bioavailability is a common hallmark of endothelial dysfunction underlying the pathogenesis of the cardiovascular dise...

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Principais autores: Anna Janaszak-Jasiecka, Agata Płoska, Joanna M. Wierońska, Lawrence W. Dobrucki, Leszek Kalinowski
Formato: Artigo
Idioma:Inglês
Publicado em: BMC 2023-03-01
coleção:Cellular & Molecular Biology Letters
Assuntos:
Cardiovascular disease
Endothelial dysfunction
eNOS uncoupling
Oxidative/nitroxidative stress
Peroxynitrite
Nitric oxide
Acesso em linha:https://doi.org/10.1186/s11658-023-00423-2
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