A pathogenic mosaic TP53 mutation in two germ layers detected by next generation sequencing.

Li-Fraumeni syndrome is caused by germline TP53 mutations and is clinically characterized by a predisposition to a range of cancers, most commonly sarcoma, brain tumours and leukemia. Pathogenic mosaic TP53 mutations have only rarely been described.We describe a 2 years old child presenting with thr...

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Ngā kaituhi matua:	Sam Behjati, Mariana Maschietto, Richard D Williams, Lucy Side, Mike Hubank, Rebecca West, Katie Pearson, Neil Sebire, Patrick Tarpey, Andrew Futreal, Tony Brooks, Michael R Stratton, John Anderson
Hōputu:	Artigo
Reo:	Inglês
I whakaputaina:	Public Library of Science (PLoS) 2014-01-01
Rangatū:	PLoS ONE
Urunga tuihono:	http://europepmc.org/articles/PMC4014518?pdf=render
Ngā Tūtohu:	Tāpirihia he Tūtohu Kāore He Tūtohu, Me noho koe te mea tuatahi ki te tūtohu i tēnei pūkete!

A pathogenic mosaic TP53 mutation in two germ layers detected by next generation sequencing.

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