Preclinical assessment of a novel human antibody VH domain targeting mesothelin as an antibody-drug conjugate

Mesothelin (MSLN) has been a validated tumor-associated antigen target for several solid tumors for over a decade, making it an attractive option for therapeutic interventions. Novel antibodies with high affinity and better therapeutic properties are needed. In the current study, we have isolated an...

Πλήρης περιγραφή

Λεπτομέρειες βιβλιογραφικής εγγραφής

Κύριοι συγγραφείς:	Zehua Sun, Xiaojie Chu, Cynthia Adams, Tatiana V. Ilina, Michel Guerrero, Guowu Lin, Chuan Chen, Dontcho Jelev, Rieko Ishima, Wei Li, John W. Mellors, Guillermo Calero, Dimiter S. Dimitrov
Μορφή:	Artigo
Γλώσσα:	Inglês
Έκδοση:	Elsevier 2023-12-01
Σειρά:	Molecular Therapy: Oncolytics
Θέματα:	VH domain library ADC MSLN in vivo distribution structure
Διαθέσιμο Online:	http://www.sciencedirect.com/science/article/pii/S2372770523000694
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