Preclinical assessment of a novel human antibody VH domain targeting mesothelin as an antibody-drug conjugate

Mesothelin (MSLN) has been a validated tumor-associated antigen target for several solid tumors for over a decade, making it an attractive option for therapeutic interventions. Novel antibodies with high affinity and better therapeutic properties are needed. In the current study, we have isolated an...

Бүрэн тодорхойлолт

Номзүйн дэлгэрэнгүй

Үндсэн зохиолчид:	Zehua Sun, Xiaojie Chu, Cynthia Adams, Tatiana V. Ilina, Michel Guerrero, Guowu Lin, Chuan Chen, Dontcho Jelev, Rieko Ishima, Wei Li, John W. Mellors, Guillermo Calero, Dimiter S. Dimitrov
Формат:	Artigo
Хэл сонгох:	Inglês
Хэвлэсэн:	Elsevier 2023-12-01
Цуврал:	Molecular Therapy: Oncolytics
Нөхцлүүд:	VH domain library ADC MSLN in vivo distribution structure
Онлайн хандалт:	http://www.sciencedirect.com/science/article/pii/S2372770523000694
Шошгууд:	Шошго нэмэх Шошго байхгүй, Энэхүү баримтыг шошголох эхний хүн болох!