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Neonatal and pediatric thymic grafts generate similar human T-cell chimerism in humanized mice

Human immune system (HIS) humanized mice, particularly those incorporating human thymic tissue and hematopoietic stem/progenitor cell (HSPC) co-transplantation, provide a powerful in vivo platform to study human T-cell development, tolerance, and effector function in the context of a full human immu...

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Autori principali: Natalia M. Del Rio, Liupei Huang, Alexis M. Holm, Wesley Blashka, Nicholas A. Smith, Sayandeep Saha, Adam J. Bell, Janell Richardson, Katherine E. Badior, Christian J. Kastrup, Matthew E. Brown
Natura: Artigo
Lingua:Inglês
Pubblicazione: Frontiers Media S.A. 2026-07-01
Serie:Frontiers in Immunology
Soggetti:
BLT mouse
humanized mouse
mRNA vaccine
NeoThy mouse
thymopoiesis
thymus transplantation
Accesso online:https://www.frontiersin.org/articles/10.3389/fimmu.2026.1852823/full
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