Neonatal and pediatric thymic grafts generate similar human T-cell chimerism in humanized mice

Human immune system (HIS) humanized mice, particularly those incorporating human thymic tissue and hematopoietic stem/progenitor cell (HSPC) co-transplantation, provide a powerful in vivo platform to study human T-cell development, tolerance, and effector function in the context of a full human immu...

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Principais autores:	Natalia M. Del Rio, Liupei Huang, Alexis M. Holm, Wesley Blashka, Nicholas A. Smith, Sayandeep Saha, Adam J. Bell, Janell Richardson, Katherine E. Badior, Christian J. Kastrup, Matthew E. Brown
Format:	Artigo
Jezik:	Inglês
Izdano:	Frontiers Media S.A. 2026-07-01
Serija:	Frontiers in Immunology
Teme:	BLT mouse humanized mouse mRNA vaccine NeoThy mouse thymopoiesis thymus transplantation
Online dostop:	https://www.frontiersin.org/articles/10.3389/fimmu.2026.1852823/full
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