Neonatal and pediatric thymic grafts generate similar human T-cell chimerism in humanized mice

Human immune system (HIS) humanized mice, particularly those incorporating human thymic tissue and hematopoietic stem/progenitor cell (HSPC) co-transplantation, provide a powerful in vivo platform to study human T-cell development, tolerance, and effector function in the context of a full human immu...

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主要な著者:	Natalia M. Del Rio, Liupei Huang, Alexis M. Holm, Wesley Blashka, Nicholas A. Smith, Sayandeep Saha, Adam J. Bell, Janell Richardson, Katherine E. Badior, Christian J. Kastrup, Matthew E. Brown
フォーマット:	Artigo
言語:	Inglês
出版事項:	Frontiers Media S.A. 2026-07-01
シリーズ:	Frontiers in Immunology
主題:	BLT mouse humanized mouse mRNA vaccine NeoThy mouse thymopoiesis thymus transplantation
オンライン･アクセス:	https://www.frontiersin.org/articles/10.3389/fimmu.2026.1852823/full
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