The non-catalytic role of DNA polymerase epsilon in replication initiation in human cells

DNA polymerase epsilon has a critical role in DNA replication initiation. Here, the authors show that in human cancer cells POLE is dispensable for the replicative helicase assembly but not for replication initiation, which requires the non-catalytic domain of POLE1.

Номзүйн дэлгэрэнгүй

Үндсэн зохиолчид:	Sameera Vipat, Dipika Gupta, Sagun Jonchhe, Hele Anderspuk, Eli Rothenberg, Tatiana N. Moiseeva
Формат:	Artigo
Хэл сонгох:	Inglês
Хэвлэсэн:	Nature Portfolio 2022-11-01
Цуврал:	Nature Communications
Онлайн хандалт:	https://doi.org/10.1038/s41467-022-34911-4
Шошгууд:	Шошго нэмэх Шошго байхгүй, Энэхүү баримтыг шошголох эхний хүн болох!