Critical roles of Dpb3-Dpb4 sub-complex of DNA polymerase epsilon in DNA replication, genome stability, and pathogenesis of Candida albicans

ABSTRACT DNA polymerase ε (Polε) is an essential replicative polymerase consisting of Pol2, Dpb2, Dpb3, and Dpb4 subunits and has not been explored in the pathogenic yeast Candida albicans. C. albicans is accountable for >40% of deaths due to systemic candidiasis per year worldwide. Genome plasticit...

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Bibliografische Detailangaben

Hauptverfasser:	Bhabasha Gyanadeep Utkalaja, Shraddheya Kumar Patel, Satya Ranjan Sahu, Abinash Dutta, Narottam Acharya
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	American Society for Microbiology 2024-10-01
Schriftenreihe:	mBio
Schlagworte:	Candida albicans DNA replication DNA polymerase whole genome sequencing systemic candidiasis virulence
Online-Zugang:	https://journals.asm.org/doi/10.1128/mbio.01227-24
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