The non-catalytic role of DNA polymerase epsilon in replication initiation in human cells

DNA polymerase epsilon has a critical role in DNA replication initiation. Here, the authors show that in human cancer cells POLE is dispensable for the replicative helicase assembly but not for replication initiation, which requires the non-catalytic domain of POLE1.

Dades bibliogràfiques

Autors principals:	Sameera Vipat, Dipika Gupta, Sagun Jonchhe, Hele Anderspuk, Eli Rothenberg, Tatiana N. Moiseeva
Format:	Artigo
Idioma:	Inglês
Publicat:	Nature Portfolio 2022-11-01
Col·lecció:	Nature Communications
Accés en línia:	https://doi.org/10.1038/s41467-022-34911-4
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