Distinct metabolic signatures of Alzheimer's and Parkinson's disease revealed through genetic overlapResearch in context

Summary: Background: Metabolic dysfunction is a major risk factor for neurodegeneration, yet the genetic architecture linking systemic metabolism to Alzheimer's disease (AD) and Parkinson's disease (PD) remains unclear. Methods: We integrated genome-wide association data for 249 circulating metabol...

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Autori principali:	Sara E. Stinson, Alexey A. Shadrin, Zillur Rahman, Linn Rødevand, Iris J. Broce, Geir Selbæk, Hreinn Stefansson, Jan Haavik, Nadine Parker, Elise Koch, Oleksandr Frei, Kevin S. O'Connell, Olav B. Smeland, Srdjan Djurovic, Anders M. Dale, Dennis van der Meer, Ole A. Andreassen
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	Elsevier 2026-05-01
Serie:	EBioMedicine
Soggetti:	Metabolomics Proglucagon Genome-wide association study Cardiometabolic disease Alzheimer's disease Parkinson's disease
Accesso online:	http://www.sciencedirect.com/science/article/pii/S2352396426001362
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