QR-koda

High prevalence of constitutional BRCA1 epimutation in patients with early-onset triple-negative breast cancer

Abstract Between 5 and 8% of the general population carry a constitutional methylation of the BRCA1 promoter (“epimutation”). Several studies have suggested that these BRCA1 epimutations confer an increased risk of breast cancer, in particular triple-negative breast cancer (TNBC), with an earlier on...

Olles dieđut

Furkejuvvon:
Váldodahkkit: Mathias Schwartz, Sabrina Ibadioune, Hélène Delhomelle, Solenn Barraud, Sandrine M. Caputo, Olfa Trabelsi-Grati, Marie-Charlotte Villy, Anthony Laugé, Roseline Tang, Etienne Rouleau, Emmanuelle Mouret-Fourme, Dominique Stoppa-Lyonnet, Éric Pasmant, Lisa Golmard, Chrystelle Colas, Ivan Bièche
Materiálatiipa: Artigo
Giella:Inglês
Almmustuhtton: BMC 2025-06-01
Ráidu:Clinical Epigenetics
Fáttát:
HBOC
Methylation
Promoter
Cancer predisposition
Epimutation
Constitutional epimutation
Liŋkkat:https://doi.org/10.1186/s13148-025-01885-1
Fáddágilkorat: Lasit fáddágilkoriid
Eai fáddágilkorat, Lasit vuosttaš fáddágilkora!

Geahča maid