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A Rapid and Reliable Test for <i>BRCA1</i> Promoter Hypermethylation in Paraffin Tissue Using Pyrosequencing

<b>Background:</b> Ovarian cancers harboring inactivating mutations in <i>BRCA1</i> or <i>BRCA2</i> demonstrate increased sensitivity to poly (ADP-ribose) polymerase inhibitors (PARPis). <i>BRCA1</i> promoter methylation could serve as a more precise biomarker for therapy response, as it reflects a...

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Autori principali: Ruben Bacares, Robert Soslow, Narciso Olvera, Douglas A. Levine, Liying Zhang
Natura: Artigo
Lingua:Inglês
Pubblicazione: MDPI AG 2025-03-01
Serie:Diagnostics
Soggetti:
BRCA
hypermethylation
pyrosequencing
Accesso online:https://www.mdpi.com/2075-4418/15/5/601
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