A Rapid and Reliable Test for <i>BRCA1</i> Promoter Hypermethylation in Paraffin Tissue Using Pyrosequencing

<b>Background:</b> Ovarian cancers harboring inactivating mutations in <i>BRCA1</i> or <i>BRCA2</i> demonstrate increased sensitivity to poly (ADP-ribose) polymerase inhibitors (PARPis). <i>BRCA1</i> promoter methylation could serve as a more precise biomarker for therapy response, as it reflects a...

ver descrição completa

Detalhes bibliográficos

Principais autores:	Ruben Bacares, Robert Soslow, Narciso Olvera, Douglas A. Levine, Liying Zhang
Formato:	Artigo
Idioma:	Inglês
Publicado em:	MDPI AG 2025-03-01
coleção:	Diagnostics
Assuntos:	BRCA hypermethylation pyrosequencing
Acesso em linha:	https://www.mdpi.com/2075-4418/15/5/601
Tags:	Adicionar Tag Sem tags, seja o primeiro a adicionar uma tag!