High prevalence of constitutional BRCA1 epimutation in patients with early-onset triple-negative breast cancer

Abstract Between 5 and 8% of the general population carry a constitutional methylation of the BRCA1 promoter (“epimutation”). Several studies have suggested that these BRCA1 epimutations confer an increased risk of breast cancer, in particular triple-negative breast cancer (TNBC), with an earlier on...

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Bibliografski detalji

Glavni autori:	Mathias Schwartz, Sabrina Ibadioune, Hélène Delhomelle, Solenn Barraud, Sandrine M. Caputo, Olfa Trabelsi-Grati, Marie-Charlotte Villy, Anthony Laugé, Roseline Tang, Etienne Rouleau, Emmanuelle Mouret-Fourme, Dominique Stoppa-Lyonnet, Éric Pasmant, Lisa Golmard, Chrystelle Colas, Ivan Bièche
Format:	Artigo
Jezik:	Inglês
Izdano:	BMC 2025-06-01
Serija:	Clinical Epigenetics
Teme:	HBOC Methylation Promoter Cancer predisposition Epimutation Constitutional epimutation
Online pristup:	https://doi.org/10.1186/s13148-025-01885-1
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