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Investigator-initiated phase I trial of an oligonucleotide therapeutic targeting long noncoding RNA TUG 1 for recurrent glioblastoma

Abstract Background Glioblastoma (GB) is the most common and aggressive primary malignant brain tumor in adults. To date, no effective treatment has been reported for recurrent GB (rGB). Long noncoding RNA taurine upregulated gene 1 (TUG1), which is highly expressed in GB, resolves the formation of...

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Principais autores: Shoichi Deguchi, Fumiharu Ohka, Yoshiki Shiba, Junya Yamaguchi, Aya Sato, Keiko Shinjo, Yoshiki Arakawa, Yoshitaka Narita, Yutaka Kondo, Ryuta Saito
Formato: Artigo
Idioma:Inglês
Publicado em: BMC 2025-02-01
coleção:BMC Cancer
Assuntos:
Recurrent glioblastoma
TUG1
TUGIASO
Long noncoding RNA
Acesso em linha:https://doi.org/10.1186/s12885-025-13623-0
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