Investigator-initiated phase I trial of an oligonucleotide therapeutic targeting long noncoding RNA TUG 1 for recurrent glioblastoma

Abstract Background Glioblastoma (GB) is the most common and aggressive primary malignant brain tumor in adults. To date, no effective treatment has been reported for recurrent GB (rGB). Long noncoding RNA taurine upregulated gene 1 (TUG1), which is highly expressed in GB, resolves the formation of...

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Autores principales:	Shoichi Deguchi, Fumiharu Ohka, Yoshiki Shiba, Junya Yamaguchi, Aya Sato, Keiko Shinjo, Yoshiki Arakawa, Yoshitaka Narita, Yutaka Kondo, Ryuta Saito
Formato:	Artigo
Lenguaje:	Inglês
Publicado:	BMC 2025-02-01
Colección:	BMC Cancer
Materias:	Recurrent glioblastoma TUG1 TUGIASO Long noncoding RNA
Acceso en línea:	https://doi.org/10.1186/s12885-025-13623-0
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