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Integrated transcriptomics identifies ER stress–associated apoptosis in post-resuscitation AKI and supports early Dl-3-n-butylphthalide–associated renoprotection in a porcine TCA model

BackgroundDl-3-n-butylphthalide (NBP) is a small-molecule compound derived from celery seeds with anti-inflammatory, antioxidant, and anti-apoptotic properties. Although NBP has shown protective effects in various kidney diseases, its role in traumatic cardiac arrest (TCA)-induced acute kidney injur...

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Principais autores: Kechun Zhou, Wang Du, Yi Chen, Yufeng Hu, Pin Lan
Format: Artigo
Sprog:Inglês
Udgivet: Frontiers Media S.A. 2026-06-01
Serier:Frontiers in Pharmacology
Fag:
acute kidney injury
apoptosis
dl-3-n-butylphthalide
endoplasmic reticulum stress
traumatic cardiac arrest
Online adgang:https://www.frontiersin.org/articles/10.3389/fphar.2026.1841271/full
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