Usp7 regulates Hippo pathway through deubiquitinating the transcriptional coactivator Yorkie

Hippo signaling leads to the phosphorylation of the key transcriptional effector, Yap/Yki, although how Yap/Yki stability is regulated has remained unclear. Here, Sun et al. identify HAUSP/Usp7 as a conserved and clinically relevant regulator of the Hippo pathway that increases Yap/Yki stability.

Detalhes bibliográficos

Principais autores:	Xiaohan Sun, Yan Ding, Meixiao Zhan, Yan Li, Dongqing Gao, Guiping Wang, Yang Gao, Yong Li, Shian Wu, Ligong Lu, Qingxin Liu, Zizhang Zhou
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Nature Portfolio 2019-01-01
Colecção:	Nature Communications
Acesso em linha:	https://doi.org/10.1038/s41467-019-08334-7
Tags:	Adicionar Tag Sem tags, seja o primeiro a adicionar uma tag!