Usp7 regulates Hippo pathway through deubiquitinating the transcriptional coactivator Yorkie
Hippo signaling leads to the phosphorylation of the key transcriptional effector, Yap/Yki, although how Yap/Yki stability is regulated has remained unclear. Here, Sun et al. identify HAUSP/Usp7 as a conserved and clinically relevant regulator of the Hippo pathway that increases Yap/Yki stability.
Furkejuvvon:
| Váldodahkkit: | , , , , , , , , , , , |
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| Materiálatiipa: | Artigo |
| Giella: | Inglês |
| Almmustuhtton: |
Nature Portfolio
2019-01-01
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| Ráidu: | Nature Communications |
| Liŋkkat: | https://doi.org/10.1038/s41467-019-08334-7 |
| Fáddágilkorat: |
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