Usp7 regulates Hippo pathway through deubiquitinating the transcriptional coactivator Yorkie

Hippo signaling leads to the phosphorylation of the key transcriptional effector, Yap/Yki, although how Yap/Yki stability is regulated has remained unclear. Here, Sun et al. identify HAUSP/Usp7 as a conserved and clinically relevant regulator of the Hippo pathway that increases Yap/Yki stability.

Bibliografische Detailangaben

Hauptverfasser:	Xiaohan Sun, Yan Ding, Meixiao Zhan, Yan Li, Dongqing Gao, Guiping Wang, Yang Gao, Yong Li, Shian Wu, Ligong Lu, Qingxin Liu, Zizhang Zhou
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	Nature Portfolio 2019-01-01
Schriftenreihe:	Nature Communications
Online-Zugang:	https://doi.org/10.1038/s41467-019-08334-7
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