Non-specific irreversible 89Zr-mAb uptake in tumours: evidence from biopsy-proven target-negative tumours using 89Zr-immuno-PET

Abstract Background Distribution of mAbs into tumour tissue may occur via different processes contributing differently to the 89Zr-mAb uptake on PET. Target-specific binding in tumours is of main interest; however, non-specific irreversible uptake may also be present, which influences quantification...

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Principais autores:	Jessica E. Wijngaarden, Yvonne W. S. Jauw, Gerben J. C. Zwezerijnen, Berlinda J. de Wit-van der Veen, Daniëlle J. Vugts, Josée M. Zijlstra, Guus A. M. S. van Dongen, Ronald Boellaard, C. Willemien Menke-van der Houven van Oordt, Marc C. Huisman
Formato:	Artigo
Idioma:	Inglês
Publicado em:	SpringerOpen 2024-02-01
coleção:	EJNMMI Research
Assuntos:	Positron emission tomography Monoclonal antibodies Zirconium-89 Molecular imaging
Acesso em linha:	https://doi.org/10.1186/s13550-024-01079-5
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