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Single-cell analysis of neoplastic plasma cells identifies myeloma pathobiology mediators and potential targets

Summary: Multiple myeloma is a clonal plasma cell (PC) dyscrasia that arises from precursors and has been studied utilizing approaches focused on CD138+ cells. By combining single-cell RNA sequencing (scRNA-seq) with scB-cell receptor sequencing (scBCR-seq), we differentiate monoclonal/neoplastic fr...

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Автори: Luz Yurany Moreno Rueda, Hua Wang, Keiko Akagi, Minghao Dang, Amishi Vora, Li Qin, Hans C. Lee, Krina K. Patel, Pei Lin, David E. Mery, Fenghuang Zhan, John D. Shaughnessy, Jr., Qing Yi, Yang Song, Bo Jiang, Maura L. Gillison, Sheeba K. Thomas, Donna M. Weber, Lixia Diao, Jing Wang, Isere Kuiatse, Elisabet E. Manasanch, David E. Symer, Robert Z. Orlowski
Формат: Artigo
Мова:Inglês
Опубліковано: Elsevier 2025-02-01
Серія:Cell Reports Medicine
Предмети:
myeloma precursors
disease progression
scRNA-seq
scBCR-seq
LAMP5
MAT2A
Онлайн доступ:http://www.sciencedirect.com/science/article/pii/S2666379124006967
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