Single-cell analysis of neoplastic plasma cells identifies myeloma pathobiology mediators and potential targets

Summary: Multiple myeloma is a clonal plasma cell (PC) dyscrasia that arises from precursors and has been studied utilizing approaches focused on CD138+ cells. By combining single-cell RNA sequencing (scRNA-seq) with scB-cell receptor sequencing (scBCR-seq), we differentiate monoclonal/neoplastic fr...

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主要な著者:	Luz Yurany Moreno Rueda, Hua Wang, Keiko Akagi, Minghao Dang, Amishi Vora, Li Qin, Hans C. Lee, Krina K. Patel, Pei Lin, David E. Mery, Fenghuang Zhan, John D. Shaughnessy, Jr., Qing Yi, Yang Song, Bo Jiang, Maura L. Gillison, Sheeba K. Thomas, Donna M. Weber, Lixia Diao, Jing Wang, Isere Kuiatse, Elisabet E. Manasanch, David E. Symer, Robert Z. Orlowski
フォーマット:	Artigo
言語:	Inglês
出版事項:	Elsevier 2025-02-01
シリーズ:	Cell Reports Medicine
主題:	myeloma precursors disease progression scRNA-seq scBCR-seq LAMP5 MAT2A
オンライン･アクセス:	http://www.sciencedirect.com/science/article/pii/S2666379124006967
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