Preliminary Analysis of the Proportion and Characteristics of Dual BCR B Cells in SLE Model Mice and Patients via scRNA-Seq Combined with scBCR-Seq Technology

Systemic lupus erythematosus (SLE) is an autoimmune disease characterized by immune dysregulation and multi-organ damage. Abnormal B cell activation and autoantibody production constitute the core pathological mechanism of SLE. However, the proportion, BCR pairing types, clonal evolution patterns, a...

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Detalhes bibliográficos

Principais autores:	Kai Quan, Hongxia Yang, Guangtian Tang, Ziwei Li, Hailin Zou, Jing Ma, Xinsheng Yao
Formato:	Artigo
Idioma:	Inglês
Publicado em:	MDPI AG 2026-05-01
Colecção:	Cells
Assuntos:	systemic lupus erythematosus (SLE) BCR CDR3 repertoire dual BCR B cells single-cell RNA sequencing single-cell VDJ (BCR) sequencing
Acesso em linha:	https://www.mdpi.com/2073-4409/15/10/914
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