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HTS and scRNA-seq revealed that the location and RSS quality of the mammalian TRBV and TRBJ genes impact biased rearrangement

Abstract The quality of Recombination signal sequences (RSSs), location, and genetics of mammalian V, D, and J genes synergistically affect the recombination frequency of genes; however, the specific regulatory mechanism and efficiency have not been elucidated. By taking advantage of single-cell RNA...

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Principais autores: Yingjie Wu, Fengli Wu, Qingqing Ma, Jun Li, Long Ma, Hou Zhou, Yadong Gong, Xinsheng Yao
Format: Artigo
Sprog:Inglês
Udgivet: BMC 2024-10-01
Serier:BMC Genomics
Fag:
Mammalian TRB locus
V(D)J rearrangement
Recombination signal sequences
TCR CDR3 repertoire
single-cell RNA sequencing
High-throughput sequencing
Online adgang:https://doi.org/10.1186/s12864-024-10887-x
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