HTS and scRNA-seq revealed that the location and RSS quality of the mammalian TRBV and TRBJ genes impact biased rearrangement

Abstract The quality of Recombination signal sequences (RSSs), location, and genetics of mammalian V, D, and J genes synergistically affect the recombination frequency of genes; however, the specific regulatory mechanism and efficiency have not been elucidated. By taking advantage of single-cell RNA...

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Principais autores:	Yingjie Wu, Fengli Wu, Qingqing Ma, Jun Li, Long Ma, Hou Zhou, Yadong Gong, Xinsheng Yao
פורמט:	Artigo
שפה:	Inglês
יצא לאור:	BMC 2024-10-01
סדרה:	BMC Genomics
נושאים:	Mammalian TRB locus V(D)J rearrangement Recombination signal sequences TCR CDR3 repertoire single-cell RNA sequencing High-throughput sequencing
גישה מקוונת:	https://doi.org/10.1186/s12864-024-10887-x
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