Membrane protein CRISPR screen identifies RPSA as an essential host factor for porcine epidemic diarrhea virus replication

ABSTRACT Porcine epidemic diarrhea, caused by porcine epidemic diarrhea virus (PEDV), is one of the most devastating diseases in the global pig industry due to its high mortality rate in piglets. The host factors required for PEDV replication, including receptors, remain poorly understood. Here, we...

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Autores principales: Yu Zhao, Guanghao Guo, Yumei Sun, Mengjia Zhang, Gan Yang, Zhongzhu Liu, Yanbin Song, Ahmed H. Ghonaim, Ningning Ma, Mengdi Zhang, Anan Jongkaewwattana, Qigai He, Wentao Li
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Microbiology 2025-08-01
Colección:Journal of Virology
Materias:
Porcine epidemic diarrhea virus
CRISPR/Cas9
RPSA
ERK1/2 pathway
lipid metabolism
aminopeptidase N
Acceso en línea:https://journals.asm.org/doi/10.1128/jvi.00649-25
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