The HDAC Inhibitor Phenylbutyrate Reverses Effects of Neonatal Ventral Hippocampal Lesion in Rats

Recent evidence suggests that epigenetic mechanisms play a role in psychiatric diseases. In this study, we considered rats with neonatal ventral hippocampal lesions (NVHL) that are currently used for modeling neurodevelopmental aspects of schizophrenia. Contribution of epigenetic regulation to the e...

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Autors principals:	Guy eSandner, Lionel eHost, Marie-Josée eAngst, Thierry eGuiberteau, Blandine eGuignard, Jean eZwiller
Format:	Artigo
Idioma:	Inglês
Publicat:	Frontiers Media S.A. 2011-01-01
Col·lecció:	Frontiers in Psychiatry
Matèries:	Epigenetic regulation Animal model of schizophrenia Brain ontogenesis Histone deacetylase inhibitor Ventral hippocampal lesion
Accés en línia:	http://journal.frontiersin.org/Journal/10.3389/fpsyt.2010.00153/full
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