Tyloxapol inhibits RANKL-stimulated osteoclastogenesis and ovariectomized-induced bone loss by restraining NF-κB and MAPK activation

Objective: Tyloxapol is a non-ionic surfactant with diverse pharmacological effects including anti-inflammatory, anti-malignant tumor and antioxidant activities. However, the effect of tyloxapol on osteoclastogenesis has not been elucidated. In this study, we intended to clarify the effect of tyloxa...

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Autori principali:	Wen Guo, Haijun Li, Yan Lou, Yue Zhang, Jia Wang, Ming Qian, Haifeng Wei, Jianru Xiao, Youjia Xu
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	Elsevier 2021-05-01
Serie:	Journal of Orthopaedic Translation
Soggetti:	Tyloxapol Osteoporosis Osteoclast Osteoblast Nuclear factor kappa-B (NF-κB) Mitogen-activated protein kinase (MAPK)
Accesso online:	http://www.sciencedirect.com/science/article/pii/S2214031X21000061
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