Apolipoprotein L1 (APOL1): Consideration of Molecular Evolution, Interaction with APOL3, and Impact of Splice Isoforms Advances Understanding of Cellular and Molecular Mechanisms of Cell Injury

The Apolipoprotein L1 (APOL1) innate immunity gene product represents the sole member of the APOL gene family in humans capable of secretion into circulation, thereby mediating the trypanolysis of <i>T. brucei brucei</i>. Gain-of-function variants of the APOL1 gene originated and spread among human...

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Prif Awduron:	Razi Khalaila, Karl Skorecki
Fformat:	Artigo
Iaith:	Inglês
Cyhoeddwyd:	MDPI AG 2025-07-01
Cyfres:	Cells
Pynciau:	trypanosomiasis trypanosome lytic factor APOL1 risk variants APOL1 splice variants APOL3 signal peptide
Mynediad Ar-lein:	https://www.mdpi.com/2073-4409/14/13/1011
Tagiau:	Ychwanegu Tag Dim Tagiau, Byddwch y cyntaf i dagio'r cofnod hwn!