Small molecule modulation of p75NTR engages the autophagy-lysosomal pathway and reduces huntingtin aggregates in cellular and mouse models of Huntington's disease

Huntington's disease (HD) is a neurodegenerative disorder caused by a CAG repeat expansion in the HTT gene encoding a mutant huntingtin (mHtt) protein. mHtt aggregates within neurons causing degeneration primarily in the striatum. There is currently a need for disease-modifying treatments for HD. Ma...

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Principais autores:	Danielle A. Simmons, Namitha Alexander, Gloria Cao, Ido Rippin, Yarine Lugassy, Hagit Eldar-Finkelman, Frank M. Longo
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Elsevier 2025-03-01
Colecção:	Neurotherapeutics
Assuntos:	Neurotrophin Huntingtin inclusions Neurodegeneration Autophagy p75NTR
Acesso em linha:	http://www.sciencedirect.com/science/article/pii/S187874792400182X
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