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mTOR/α-ketoglutarate-mediated signaling pathways in the context of brain neurodegeneration and neuroprotection

Cerebral disorders are largely associated with impaired cellular metabolism, despite the regulatory mechanisms designed to ensure cell viability and adequate brain function. Mechanistic target of rapamycin (mTOR) signaling is one of the most crucial factors in the regulation of energy homeostasis an...

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Principais autores: Olha Kostiuchenko, Iryna Lushnikova, Magdalena Kowalczyk, Galyna Skibo
Format: Artigo
Sprog:Inglês
Udgivet: Elsevier 2022-01-01
Serier:BBA Advances
Fag:
mTOR
α-ketoglutarate (AKG)
Metabolism
Autophagy
Aging
Neurodegeneration
Online adgang:http://www.sciencedirect.com/science/article/pii/S2667160322000266
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