BVR-A Deficiency Leads to Autophagy Impairment through the Dysregulation of AMPK/mTOR Axis in the Brain—Implications for Neurodegeneration

Biliverdin reductase-A (BVR-A) impairment is associated with increased accumulation of oxidatively-damaged proteins along with the impairment of autophagy in the brain during neurodegenerative disorders. Reduced autophagy inhibits the clearance of misfolded proteins, which then form neurotoxic aggre...

पूर्ण विवरण

ग्रंथसूची विवरण

मुख्य लेखकों:	Chiara Lanzillotta, Ilaria Zuliani, Chirag Vasavda, Solomon H. Snyder, Bindu D. Paul, Marzia Perluigi, Fabio Di Domenico, Eugenio Barone
स्वरूप:	Artigo
भाषा:	Inglês
प्रकाशित:	MDPI AG 2020-07-01
श्रृंखला:	Antioxidants
विषय:	AMPK autophagy biliverdin reductase mTOR neurodegeneration oxidative stress
ऑनलाइन पहुंच:	https://www.mdpi.com/2076-3921/9/8/671
टैग:	टैग जोड़ें कोई टैग नहीं, इस रिकॉर्ड को टैग करने वाले पहले व्यक्ति बनें!