RING1B-BMI1 catalyzed dynamic H2AK119ub1 modification in response to sonic hedgehog signalling during pancreatic differentiation of human embryonic stem cells

Abstract Human embryonic stem cells (ESCs) can differentiate into the pancreatic lineage and thus can serve as in vitro models for normal pancreas development. Epigenetic modulators such as RING1B and BMI1, are essential lineage regulators of the pancreatic lineage. Inhibition of the sonic hedgehog...

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Autors principals:	Niloufer P. Dumasia, Prasad S. Pethe
Format:	Artigo
Idioma:	Inglês
Publicat:	Nature Portfolio 2025-11-01
Col·lecció:	Scientific Reports
Matèries:	BMI1 Chromatin Immunoprecipitation Polycomb group proteins Pancreatic progenitors RING1B
Accés en línia:	https://doi.org/10.1038/s41598-025-27698-z
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