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Mutant glucocorticoid receptor binding elements on the interleukin-6 promoter regulate dexamethasone effects

Abstract Background Glucocorticoids (GCs) have been extensively used as essential modulators in clinical infectious and inflammatory diseases. The GC receptor (GR) is a transcription factor belonging to the nuclear receptor family that regulates anti-inflammatory processes and releases pro-inflammat...

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Principais autores: Wen-Teng Chang, Ming-Yuan Hong, Chien-Liang Chen, Chi-Yuan Hwang, Cheng-Chieh Tsai, Chia-Chang Chuang
Format: Artigo
Sprog:Inglês
Udgivet: BMC 2021-03-01
Serier:BMC Immunology
Fag:
Glucocorticoid receptor
Interleukin-6
Lipopolysaccharide
Dexamethasone
Promoter activity
Transcriptional factor
Online adgang:https://doi.org/10.1186/s12865-021-00413-z
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