Mutant glucocorticoid receptor binding elements on the interleukin-6 promoter regulate dexamethasone effects

Abstract Background Glucocorticoids (GCs) have been extensively used as essential modulators in clinical infectious and inflammatory diseases. The GC receptor (GR) is a transcription factor belonging to the nuclear receptor family that regulates anti-inflammatory processes and releases pro-inflammat...

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Detalhes bibliográficos

Principais autores:	Wen-Teng Chang, Ming-Yuan Hong, Chien-Liang Chen, Chi-Yuan Hwang, Cheng-Chieh Tsai, Chia-Chang Chuang
Formato:	Artigo
Idioma:	Inglês
Publicado em:	BMC 2021-03-01
coleção:	BMC Immunology
Assuntos:	Glucocorticoid receptor Interleukin-6 Lipopolysaccharide Dexamethasone Promoter activity Transcriptional factor
Acesso em linha:	https://doi.org/10.1186/s12865-021-00413-z
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