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CLIP2: a novel functional player in AQP5 trafficking dynamics and implications for Sjögren’s disease

Abstract Background Sjögren’s disease (SjD) is an autoimmune condition affecting exocrine glands, resulting in decreased saliva and tear production. Aquaporin 5 (AQP5) is a transmembrane water channel playing a central role in water transport. In SjD, deregulation of AQP5 expression, trafficking and...

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Principais autores: Claudia D’Agostino, Nikola Filipovic, Egor Zindy, Louise Conrard, Zhen Wang, Stefania Moscato, Fiona Engelke, Angelica Nash, Carl Johan Hagströmer, Helin Strandberg, Dorian Parisis, Azine Datlibagi, Françoise Gregoire, Nargis Bolaky, Maxime Tarabichi, Muhammad Shahnawaz Soyfoo, Kevin L. Schey, Thomas Dörner, Torsten Witte, Jason Perret, Letizia Mattii, Susanna Törnroth-Horsefield, Christine Delporte
Formato: Artigo
Idioma:Inglês
Publicado em: BMC 2025-11-01
coleção:Cell Communication and Signaling
Assuntos:
Aquaporin 5
Autoantibodies
CAP-Gly Domain Containing LinkerProtein
Protein-protein interaction
Salivary gland
Sjöögren's disease
Acesso em linha:https://doi.org/10.1186/s12964-025-02476-6
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