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Glutathione responsive iNOS inhibiting polymeric prodrug for targeted Inhibition of angiogenesis

Abstract Background Inducible nitric oxide synthase (iNOS) is a key driver of aberrant angiogenesis in inflammatory conditions and cancer, making it an attractive therapeutic target. Nevertheless, its function can be affected by the complex immune responses and tumor microenvironment (TME). Hence, c...

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Principais autores: Houman Alimoradi, Anita Fallah, Pascale Jespers, Nargis Bolaky, Françoise Gregoire, Helen Townley, Susanna Törnroth-Horsefield, Armin Shavandi, Laurence Dewachter, Christine Delporte
Format: Artigo
Sprog:Inglês
Udgivet: BMC 2026-01-01
Serier:Journal of Nanobiotechnology
Fag:
Angiogenesis
Gluthatione-responsive prodrug
iNOS
Nitric oxide
Tumor microenvironment
Online adgang:https://doi.org/10.1186/s12951-026-04022-z
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