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Molecular, clinicopathological, and immune correlates of LAG3 promoter DNA methylation in melanoma

Background: The co-receptor lymphocyte-activation gene-3 (LAG3, LAG-3, CD223) is a potential target for immune checkpoint inhibition immunotherapies. However, little is known about the biological and clinical significance of LAG3 DNA methylation in melanoma and its microenvironment. Methods: We eval...

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Hoofdauteurs: Anne Fröhlich, Judith Sirokay, Simon Fietz, Timo J. Vogt, Jörn Dietrich, Romina Zarbl, Mike Florin, Pia Kuster, Gonzalo Saavedra, Susana Ramírez Valladolid, Friederike Hoffmann, Lukas Flatz, Sandra S. Ring, Carsten Golletz, Torsten Pietsch, Sebastian Strieth, Peter Brossart, Gerrit H. Gielen, Glen Kristiansen, Friedrich Bootz, Jennifer Landsberg, Dimo Dietrich
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Elsevier 2020-09-01
Reeks:EBioMedicine
Onderwerpen:
LAG3
DNA Methylation
Melanoma
Predictive Biomarker
Immunotherapy
Online toegang:http://www.sciencedirect.com/science/article/pii/S2352396420303388
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