Molecular, clinicopathological, and immune correlates of LAG3 promoter DNA methylation in melanoma

Background: The co-receptor lymphocyte-activation gene-3 (LAG3, LAG-3, CD223) is a potential target for immune checkpoint inhibition immunotherapies. However, little is known about the biological and clinical significance of LAG3 DNA methylation in melanoma and its microenvironment. Methods: We eval...

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Principais autores:	Anne Fröhlich, Judith Sirokay, Simon Fietz, Timo J. Vogt, Jörn Dietrich, Romina Zarbl, Mike Florin, Pia Kuster, Gonzalo Saavedra, Susana Ramírez Valladolid, Friederike Hoffmann, Lukas Flatz, Sandra S. Ring, Carsten Golletz, Torsten Pietsch, Sebastian Strieth, Peter Brossart, Gerrit H. Gielen, Glen Kristiansen, Friedrich Bootz, Jennifer Landsberg, Dimo Dietrich
Formato:	Artigo
Idioma:	Inglês
Publicado:	Elsevier 2020-09-01
Series:	EBioMedicine
Assuntos:	LAG3 DNA Methylation Melanoma Predictive Biomarker Immunotherapy
Acceso en liña:	http://www.sciencedirect.com/science/article/pii/S2352396420303388
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