Integrative GWAS and Mendelian Randomization Analysis Identifies IREB2 and CD27+ Memory B Cells as Core Drivers of COPD to Lung Cancer Progression

ABSTRACT Chronic obstructive pulmonary disease (COPD) associates with increased lung cancer incidence and shares genetic susceptibility, yet its independent causal role and driver mechanisms are poorly understood. We integrated data from the National Health and Nutrition Examination Survey (NHANES)...

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Autors principals:	Erkang Yi, Qingyang Li, Wenqian Wu, Chengshu Xie, Hairong Wang, Erping Long, Fan Wu, Xuanyi Lu, Yu Liu, Ruiting Sun, Xinqing Lin, Xiaohong Xie, Yumin Zhou, Chengzhi Zhou, Pixin Ran
Format:	Artigo
Idioma:	Inglês
Publicat:	Wiley 2025-12-01
Col·lecció:	MedComm
Matèries:	chronic obstructive pulmonary disease GWAS IREB2 lung cancer mendelian randomization
Accés en línia:	https://doi.org/10.1002/mco2.70473
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